Pesquisa | BVS IEC

1.

First-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure.

Zwirner, Stefan; Abu Rmilah, Anan A; Klotz, Sabrina; Pfaffenroth, Bent; Kloevekorn, Philip; Moschopoulou, Athina A; Schuette, Svenja; Haag, Mathias; Selig, Roland; Li, Kewei; Zhou, Wei; Nelson, Erek; Poso, Antti; Chen, Harvey; Amiot, Bruce; Jia, Yao; Minshew, Anna; Michalak, Gregory; Cui, Wei; Rist, Elke; Longerich, Thomas; Jung, Birgit; Felgendreff, Philipp; Trompak, Omelyan; Premsrirut, Prem K; Gries, Katharina; Muerdter, Thomas E; Heinkele, Georg; Wuestefeld, Torsten; Shapiro, David; Weissbach, Markus; Koenigsrainer, Alfred; Sipos, Bence; Ab, Eiso; Zacarias, Magdalena Ortiz; Theisgen, Stephan; Gruenheit, Nicole; Biskup, Saskia; Schwab, Matthias; Albrecht, Wolfgang; Laufer, Stefan; Nyberg, Scott; Zender, Lars.

Cell ; 187(7): 1666-1684.e26, 2024 Mar 28.

Artigo em Inglês | MEDLINE | ID: mdl-38490194

2.

Humanized mouse liver reveals endothelial control of essential hepatic metabolic functions.

Kaffe, Eleanna; Roulis, Manolis; Zhao, Jun; Qu, Rihao; Sefik, Esen; Mirza, Haris; Zhou, Jing; Zheng, Yunjiang; Charkoftaki, Georgia; Vasiliou, Vasilis; Vatner, Daniel F; Mehal, Wajahat Z; Flavell, Richard A.

Cell ; 186(18): 3793-3809.e26, 2023 08 31.

Artigo em Inglês | MEDLINE | ID: mdl-37562401

3.

Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches.

Guilliams, Martin; Bonnardel, Johnny; Haest, Birthe; Vanderborght, Bart; Wagner, Camille; Remmerie, Anneleen; Bujko, Anna; Martens, Liesbet; Thoné, Tinne; Browaeys, Robin; De Ponti, Federico F; Vanneste, Bavo; Zwicker, Christian; Svedberg, Freya R; Vanhalewyn, Tineke; Gonçalves, Amanda; Lippens, Saskia; Devriendt, Bert; Cox, Eric; Ferrero, Giuliano; Wittamer, Valerie; Willaert, Andy; Kaptein, Suzanne J F; Neyts, Johan; Dallmeier, Kai; Geldhof, Peter; Casaert, Stijn; Deplancke, Bart; Ten Dijke, Peter; Hoorens, Anne; Vanlander, Aude; Berrevoet, Frederik; Van Nieuwenhove, Yves; Saeys, Yvan; Saelens, Wouter; Van Vlierberghe, Hans; Devisscher, Lindsey; Scott, Charlotte L.

Cell ; 185(2): 379-396.e38, 2022 01 20.

Artigo em Inglês | MEDLINE | ID: mdl-35021063

4.

Microscopic examination of spatial transcriptome using Seq-Scope.

Cho, Chun-Seok; Xi, Jingyue; Si, Yichen; Park, Sung-Rye; Hsu, Jer-En; Kim, Myungjin; Jun, Goo; Kang, Hyun Min; Lee, Jun Hee.

Cell ; 184(13): 3559-3572.e22, 2021 06 24.

Artigo em Inglês | MEDLINE | ID: mdl-34115981

5.

A role of PIEZO1 in iron metabolism in mice and humans.

Ma, Shang; Dubin, Adrienne E; Zhang, Yunxiao; Mousavi, Seyed Ali Reza; Wang, Yu; Coombs, Adam M; Loud, Meaghan; Andolfo, Immacolata; Patapoutian, Ardem.

Cell ; 184(4): 969-982.e13, 2021 02 18.

Artigo em Inglês | MEDLINE | ID: mdl-33571427

6.

Phase separation drives RNA virus-induced activation of the NLRP6 inflammasome.

Shen, Chen; Li, Runzhi; Negro, Roberto; Cheng, Jiewei; Vora, Setu M; Fu, Tian-Min; Wang, Anmin; He, Kaixin; Andreeva, Liudmila; Gao, Pu; Tian, Zhigang; Flavell, Richard A; Zhu, Shu; Wu, Hao.

Cell ; 184(23): 5759-5774.e20, 2021 11 11.

Artigo em Inglês | MEDLINE | ID: mdl-34678144

7.

LECT2, a Ligand for Tie1, Plays a Crucial Role in Liver Fibrogenesis.

Xu, Meng; Xu, Hong-Hai; Lin, Yuan; Sun, Xiangnan; Wang, Li-Jing; Fang, Zhe-Ping; Su, Xue-Han; Liang, Xiang-Jing; Hu, Yang; Liu, Zhi-Min; Cheng, Yuanxiong; Wei, Yuanyuan; Li, Jiabin; Li, Li; Liu, Hong-Juan; Cheng, Zhiqiang; Tang, Na; Peng, Chao; Li, Tingting; Liu, Tengfei; Qiao, Liang; Wu, Dalei; Ding, Yan-Qing; Zhou, Wei-Jie.

Cell ; 178(6): 1478-1492.e20, 2019 09 05.

Artigo em Inglês | MEDLINE | ID: mdl-31474362

8.

Deficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease.

Hernández-Alvarez, María Isabel; Sebastián, David; Vives, Sara; Ivanova, Saska; Bartoccioni, Paola; Kakimoto, Pamela; Plana, Natalia; Veiga, Sónia R; Hernández, Vanessa; Vasconcelos, Nuno; Peddinti, Gopal; Adrover, Anna; Jové, Mariona; Pamplona, Reinald; Gordaliza-Alaguero, Isabel; Calvo, Enrique; Cabré, Noemí; Castro, Rui; Kuzmanic, Antonija; Boutant, Marie; Sala, David; Hyotylainen, Tuulia; Oresic, Matej; Fort, Joana; Errasti-Murugarren, Ekaitz; Rodrígues, Cecilia M P; Orozco, Modesto; Joven, Jorge; Cantó, Carles; Palacin, Manuel; Fernández-Veledo, Sonia; Vendrell, Joan; Zorzano, Antonio.

Cell ; 177(4): 881-895.e17, 2019 05 02.

Artigo em Inglês | MEDLINE | ID: mdl-31051106

9.

Dietary Intake Regulates the Circulating Inflammatory Monocyte Pool.

Jordan, Stefan; Tung, Navpreet; Casanova-Acebes, Maria; Chang, Christie; Cantoni, Claudia; Zhang, Dachuan; Wirtz, Theresa H; Naik, Shruti; Rose, Samuel A; Brocker, Chad N; Gainullina, Anastasiia; Hornburg, Daniel; Horng, Sam; Maier, Barbara B; Cravedi, Paolo; LeRoith, Derek; Gonzalez, Frank J; Meissner, Felix; Ochando, Jordi; Rahman, Adeeb; Chipuk, Jerry E; Artyomov, Maxim N; Frenette, Paul S; Piccio, Laura; Berres, Marie-Luise; Gallagher, Emily J; Merad, Miriam.

Cell ; 178(5): 1102-1114.e17, 2019 08 22.

Artigo em Inglês | MEDLINE | ID: mdl-31442403

10.

p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression.

Moon, Sung-Hwan; Huang, Chun-Hao; Houlihan, Shauna L; Regunath, Kausik; Freed-Pastor, William A; Morris, John P; Tschaharganeh, Darjus F; Kastenhuber, Edward R; Barsotti, Anthony M; Culp-Hill, Rachel; Xue, Wen; Ho, Yu-Jui; Baslan, Timour; Li, Xiang; Mayle, Allison; de Stanchina, Elisa; Zender, Lars; Tong, David R; D'Alessandro, Angelo; Lowe, Scott W; Prives, Carol.

Cell ; 176(3): 564-580.e19, 2019 01 24.

Artigo em Inglês | MEDLINE | ID: mdl-30580964

11.

GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis.

Yu, Haojie; Rimbert, Antoine; Palmer, Alice E; Toyohara, Takafumi; Xia, Yulei; Xia, Fang; Ferreira, Leonardo M R; Chen, Zhifen; Chen, Tao; Loaiza, Natalia; Horwitz, Nathaniel Brooks; Kacergis, Michael C; Zhao, Liping; Soukas, Alexander A; Kuivenhoven, Jan Albert; Kathiresan, Sekar; Cowan, Chad A.

Cell ; 179(6): 1276-1288.e14, 2019 11 27.

Artigo em Inglês | MEDLINE | ID: mdl-31778654

12.

Liver regeneration and inflammation: from fundamental science to clinical applications.

Campana, Lara; Esser, Hannah; Huch, Meritxell; Forbes, Stuart.

Nat Rev Mol Cell Biol ; 22(9): 608-624, 2021 09.

Artigo em Inglês | MEDLINE | ID: mdl-34079104

13.

Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids.

Hu, Huili; Gehart, Helmuth; Artegiani, Benedetta; LÖpez-Iglesias, Carmen; Dekkers, Florijn; Basak, Onur; van Es, Johan; Chuva de Sousa Lopes, Susana M; Begthel, Harry; Korving, Jeroen; van den Born, Maaike; Zou, Chenhui; Quirk, Corrine; Chiriboga, Luis; Rice, Charles M; Ma, Stephanie; Rios, Anne; Peters, Peter J; de Jong, Ype P; Clevers, Hans.

Cell ; 175(6): 1591-1606.e19, 2018 11 29.

Artigo em Inglês | MEDLINE | ID: mdl-30500538

14.

Inflammatory Cytokine TNFα Promotes the Long-Term Expansion of Primary Hepatocytes in 3D Culture.

Peng, Weng Chuan; Logan, Catriona Y; Fish, Matt; Anbarchian, Teni; Aguisanda, Francis; Álvarez-Varela, Adrián; Wu, Peng; Jin, Yinhua; Zhu, Junjie; Li, Bin; Grompe, Markus; Wang, Bruce; Nusse, Roel.

Cell ; 175(6): 1607-1619.e15, 2018 11 29.

Artigo em Inglês | MEDLINE | ID: mdl-30500539

15.

Food Perception Primes Hepatic ER Homeostasis via Melanocortin-Dependent Control of mTOR Activation.

Brandt, Claus; Nolte, Hendrik; Henschke, Sinika; Engström Ruud, Linda; Awazawa, Motoharu; Morgan, Donald A; Gabel, Paula; Sprenger, Hans-Georg; Hess, Martin E; Günther, Stefan; Langer, Thomas; Rahmouni, Kamal; Fenselau, Henning; Krüger, Marcus; Brüning, Jens C.

Cell ; 175(5): 1321-1335.e20, 2018 11 15.

Artigo em Inglês | MEDLINE | ID: mdl-30445039

16.

ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P.

Kim, Ju Youn; Garcia-Carbonell, Ricard; Yamachika, Shinichiro; Zhao, Peng; Dhar, Debanjan; Loomba, Rohit; Kaufman, Randal J; Saltiel, Alan R; Karin, Michael.

Cell ; 175(1): 133-145.e15, 2018 09 20.

Artigo em Inglês | MEDLINE | ID: mdl-30220454

17.

Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC.

Grohmann, Marcus; Wiede, Florian; Dodd, Garron T; Gurzov, Esteban N; Ooi, Geraldine J; Butt, Tariq; Rasmiena, Aliki A; Kaur, Supreet; Gulati, Twishi; Goh, Pei K; Treloar, Aislinn E; Archer, Stuart; Brown, Wendy A; Muller, Mathias; Watt, Matthew J; Ohara, Osamu; McLean, Catriona A; Tiganis, Tony.

Cell ; 175(5): 1289-1306.e20, 2018 11 15.

Artigo em Inglês | MEDLINE | ID: mdl-30454647

18.

Eating macrophages for a healthy anti-NASH meal.

Lee, Yun Sok; Olefsky, Jerrold.

Immunity ; 56(1): 3-5, 2023 01 10.

Artigo em Inglês | MEDLINE | ID: mdl-36630915

19.

Diurnal Oscillations in Liver Mass and Cell Size Accompany Ribosome Assembly Cycles.

Sinturel, Flore; Gerber, Alan; Mauvoisin, Daniel; Wang, Jingkui; Gatfield, David; Stubblefield, Jeremy J; Green, Carla B; Gachon, Frédéric; Schibler, Ueli.

Cell ; 169(4): 651-663.e14, 2017 05 04.

Artigo em Inglês | MEDLINE | ID: mdl-28475894

20.

Selective Inhibition of FOXO1 Activator/Repressor Balance Modulates Hepatic Glucose Handling.

Langlet, Fanny; Haeusler, Rebecca A; Lindén, Daniel; Ericson, Elke; Norris, Tyrrell; Johansson, Anders; Cook, Joshua R; Aizawa, Kumiko; Wang, Ling; Buettner, Christoph; Accili, Domenico.

Cell ; 171(4): 824-835.e18, 2017 Nov 02.

Artigo em Inglês | MEDLINE | ID: mdl-29056338

BVS IEC

Instituto Evandro Chagas

Configurar filtros

Sua seleção (0)

Formato de exportação:

Exportar: